Lithium Treatment Prevents Neurocognitive Deficit Resulting from Cranial Irradiation

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Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation.

Curative cancer treatment regimens often require cranial irradiation, resulting in lifelong neurocognitive deficiency in cancer survivors. This deficiency is in part related to radiation-induced apoptosis and decreased neurogenesis in the subgranular zone of the hippocampus. We show that lithium treatment protects irradiated hippocampal neurons from apoptosis and improves cognitive performance ...

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Resulting from Cranial Irradiation Lithium Treatment Prevents Neurocognitive Deficit

Curative cancer treatment regimens often require cranial irradiation, resulting in lifelong neurocognitive deficiency in cancer survivors. This deficiency is in part related to radiation-induced apoptosis and decreased neurogenesis in the subgranular zone of the hippocampus. We show that lithium treatment protects irradiated hippocampal neurons from apoptosis and improves cognitive performance ...

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ژورنال

عنوان ژورنال: Cancer Research

سال: 2006

ISSN: 0008-5472,1538-7445

DOI: 10.1158/0008-5472.can-06-2740